Fig. 1. Jun is required for axial skeletogenesis. (A) Skeletal phenotype
of Bal1;Jun
/
mice. Photograph of an adult
Bal1;Jun
/
and Junf/f
control littermate. Arrowhead indicates scoliosis. (B,C) Alcian Blue/Alizarin
Red skeletal preparations of E18.5
Bal1;Jun
/
-mutant (C) and
Junf/f control (B) embryos. Arrow in C indicates fused
atlas and axis. (D,E) Dorsal view of Alcian Blue stained E16.5
Bal1;Jun
/
-mutant (E) and
Junf/f control (D) mice. The epidermis and the neural tube
were removed to visualise vertebral cartilage. Arrowheads in E indicate
fusions of Alcian Blue-positive domains.