Development -- Ohkawara et al. 130 (10): 2129 Figure IG8

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Fig. 8. Xgly4 inhibition of elongation is rescued by the activation of the non-canonical, but not the canonical, Wnt pathway. It has previously been shown that Xdsh ${Delta}$ DIX cannot activate the canonical Wnt pathway, whereas ${Delta}$ DEP cannot activate the non-canonical pathway. Inhibition of activin-induced elongation (top left) by Xgly4Mo (41 ng; top right) was rescued by ${Delta}$ DIX (50 pg; middle right) but not by ${Delta}$ DEP (50 pg; middle left), which suggests that Xgly4 regulates the convergent extension movements by acting as a positive modulator of the non-canonical Wnt pathway upstream of Dsh. When injected alone, ${Delta}$ DEP (bottom left) and ${Delta}$ DIX (bottom right) had no effect.