Fig. 8. Quantitative clonal analysis of Numb-infected and control retinal explants.
Newborn explants were infected and analyzed as in
Fig. 7. A total of 1891 control
clones and 1704 Numb clones in nine different retinal explants were analyzed.
The results are shown as mean±s.d. (A) Clone size. (B) Proportion of
photoreceptor-only clones. (C) Proportion of photoreceptors in the total
population of infected cells analyzed. (D) Proportion of clones containing at
least one neuron, one Müller cell or more than one cell type. (E)
Proportion of interneurons or Müller cells in the total population of
infected cells analyzed. (F) Proportion of two-cell clones containing either
two photoreceptors (PR) or a photoreceptor and another cell type. In (B-F),
all of the differences between the control and Numb clones are significantly
different when analyzed by a non-parametric statistical test
(P<0.01).