Fig. 1. Epidermal abnormalities and altered differentiation in p107/p130 knockout mice. Newborn skin sections of double heterozygous (A,A') and p107/p130-null mice (B,B'). Note the decrease in the number and size of keratohyalin granules of the stratum granulosum in p107/p130-null animals (B') compared with its respective littermate (A'). Expression of the epidermal differentiation markers in double heterozygous (C-E) and p107/p130-null animals (C'-E') showing a similar expression of K10 (C,C') and a decrease in the expression of the terminal differentiation-markers filaggrin (D,D') and loricrin (E,E'). (A,A',B,B') Hematoxylin-Eosin staining. Scale bars: 100 µm.