Fig. 3. The ak mice have deficient striatal dopaminergic innervation. (A,B) Coronal sections through the left striatum of P100 wild-type (A) and ak (B) mice immunostained for TH. Rostrocaudal positions are indicated as millimeters relative to bregma in the lower right corner. Scale bar: 250 µm. (C,D) DA concentration in dorsal (C) and ventral (D) striatum of P130 wild-type and ak mice. The data are represented as the mean±s.e.m. (n=4). A statistically significant decrease in DA concentration was detected in the dorsal and ventral striatum of ak mice compared with controls (P<0.01, t-test).