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Fig. 10. Model for mechanism by which Myc stimulates exit from the stem cell compartment and differentiation into IFE and sebocytes. (A) Location of stem cell populations, showing that stem cells for IFE and sebocytes are in close proximity to their differentiated daughters, whereas the progeny of bulge stem cells migrate to the dermal papilla before differentiating along the hair lineages. (B) Comparison of the role of Myc activation in wild-type and K14MycER epidermis.