Fig. 8. Decrease in 6 integrin levels and hemidesmosomes by activation of Myc. (A,B) Immunolabelling of the epidermis with antibodies to 6 of (A) wild-type mice or (B) transgenic mice after 4 days treatment with OHT. (C-F) Electron microscopy of the basement membrane zone of skin from transgenic mice (D,F) and wild-type mice (C,E) treated for 9 days with OHT. Arrows in C, D and E indicate hemidesmosomes. Arrows in F indicate absence of hemidesmosomes at the basement membrane. Scale bars: 5 µm (B), 200 nm (D), 1 µm (F). BM, basement membrane; IFE, interfollicular epidermis; HF, hair follicle.