Fig. 5. cls/sox10 response of nac/mitfa promoter luciferase reporter constructs with mutated Cls/Sox10 binding sites (see Table 1). cls/sox10 response is measured as: (luciferase activity in NIH3T3 cells co-transfected with reporter and pCS2Sox10)/(activity with reporter and pCS2Sox10L142Q). Mean values from five or more repetitions of each experiment are shown for Fspnac>luc (Fsp), FspM1nac>luc (FspM1), FspM2nac>luc (FspM2), FspM3nac>luc (FspM3), FspM4nac>luc (FspM4), FspM1M3nac>luc (FspM1M3) and FspM3M4nac>luc. Bars indicate s.e.m.