Development -- Dakubo et al. 130 (13): 2967 Figure IG3

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Fig. 3. Craniofacial phenotype and Hh target gene expression in the retina of wild-type and ThyCreShh^n/c mice. (A,D) Photographs of E17 embryos showing that ThyCreShh^n/c embryos (D) develop well separated bilateral eyes but, compared with wild type (A), have hypoplastic craniofacial structures and failed eyelid closure. (B,C,E,F) Expression of Hh target genes in retinal neuroblasts of E17 wild-type (B,C) and ThyCreShh^n/c embryos (E,F) reveals a marked downregulation of Gli (E) and Ptch (F) expression in the retina of ThyCreShh^n/c embryos in comparison with wild-type littermates (B,C). Arrows (E,F) point to retinal neuroblasts responding to Shh signaling from a few RGCs that escaped Cre-mediated recombination of the Shh allele in this part of the retina.