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Fig. 7. Progenitors of asymmetric Eve lineage adopt a pericardial EPC cell fate in numb,CycA double mutants. (A-F) A2-A7 hemisegments of stage 13 embryos labeled for Mef2 (green) and Eve (red). (A-C) In CycA mutants, no EPCs only DA1 muscles, whereas in numb mutants, up to four EPCs but no DA1 muscles are present in each hemisegment. Both CycA and numb single mutants show four instead of six myocardial cells per hemisegment. (D) Double mutants of numb and CycA show two myocardial cells and a EPC in each hemisegment. (E) Embryos overexpressing N(icd) with heat shock promoter (see Park et al., 1998) exhibit twice the normal number of EPCs as do numb mutants. (F) Overexpression of N(icd) in CycA mutant embryos, as in numb,CycA double mutants, also produces one EPC and two myocardial cells per hemisegment.