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Fig. 4. Alignment of the PTP domains of SDF-9 and known PTPs. Conserved residues and homologous residues (gray) are boxed. The active site of PTP is underlined. The cysteine residue (Cys 223) that is essential for phosphatase activity is replaced by serine in SDF-9. HsRPTPA-D1: human receptor PTP alpha proximal domain, HsRPTPA-D2: human receptor PTP alpha distal domain, HsPTP1B: human PTP1B.