Fig. 2. Epistasis analysis of Dmkp3 overexpression. A direct sev-Dmkp3 transgene causes rough eyes (section in D, compare to wild-type in Fig. 1A), which are enhanced by rl^10A (G). Note that the direct sev-Dmkp3 construct causes the loss of outer and central photoreceptors, whereas the sev-GAL4 driven Dmkp3 mainly affects the R3/R4 pair, indicating that the time-window for ERK-dependent differentiation is shorter in R7 cells than in R3/R4 cells (Fig. 1P). The construct almost completely rescues sev^S11 (E,H) and rl^SEM (F,I) eyes. However, the rl^SEM wing phenotype (B) is unaffected by en-GAL4³³-driven UAS-Dmkp3 (A,C). (The line marks the anterior-posterior wing boundary.) Specimens shown in A-C,F,I are from males.