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Fig. 2. Reduced TrkA protein in P0 Brn3a-null or double-null trigeminal ganglia. Low (A1-A4) and high (B1-B4) magnification pictures of peripherin immunostaining, showing that all four genotypes have similar levels of peripherin in trigeminal ganglia. Low (C1-C4) and high (D1-D4) magnification pictures of TrkA immunostaining, showing that Brn3a-null (C3,D3) and double-null (C4,D4) ganglia have reduced TrkA protein compared with control (C1,D1) and Bax-null (C2,D2) ganglia, respectively. (E1-E4) Brn3a immunostaining showing that Brn3a-null (E3) and double-null (E4) ganglia lack nuclear Brn3a protein compared with control (E1) and Bax-null (E2) ganglia. Double-null ganglia are always larger and have more neurons than Brn3a-null ganglia.