Fig. 4. The Dishevelled-dependent WNT/PCP pathway is not required for
GATA4-mediated cardiogenesis. Injection of Dishevelled (Dsh)
PDZ
dominant-negative construct, which inhibits both canonical and PCP WNT
pathways, does not alter induction of the cardiac marker MLC2 by GATA4 and
Cerberus. Similarly, Dishevelled DEP+, a PCP pathway-specific
dominant-negative construct, does not affect induction of MLC2 by GATA4.