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Fig. 2. Smo overexpression progressively activates Hh responses. (A-E) Wild type, (F-N) hemizygous MS1096, which express Gal4 throughout the wing pouch, higher dorsally than ventrally and highest in the dorsal hinge (K). (F-J) UasSmo 4x, (L-O) UasSmohigh. (B,G,L) Iro, with bracket indicating the L3 region, (C,H,M) dpp, (D,I,N) ptc, (E,J,O) col. UasSmo 4x increased venation (F) and expanded Iro and dpp (G,H), but had little effect on ptc or col (I,J). High UasSmo expanded the wing pouch and caused dorsal anterior misexpression of Iro, dpp and ptc (L-N), but not col (O). In this, and all other figures, anterior is towards the left and (for imaginal discs) ventral is upwards.