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Fig. 4. Genetically, Mesp2 lies downstream of Dll3 regarding the rostrocaudal polarity. Expression of the caudal genes Dll1 (A-D), Uncx4.1 (E-H) and the morphology of the lumbar vertebrae (I-L) are examined in the Dll3/Mesp2 intercross. Genotypes are indicated on the left. The Dll3/Mesp2 double-null embryo exhibits phenotypes indistinguishable from those of the Mesp2-null embryo. Details are stated in the text. For the rostral genes, see Fig. S1 at http://dev.biologists.org/supplemental/.