Fig. 6. Percentage donor chimerism in the blood of recipient mice transplanted with
fetal liver or adult marrow cells. (A) Fetal liver donor cells expressing Kit,
CD34 and CD41 (+++) demonstrated minimal but detectable repopulating ability
in the competitive repopulating assay, however, cells expressing Kit, CD34,
but not CD41 (++-) demonstrated high repopulating ability. (B) Adult marrow
cells expressing Kit, CD34, and CD41 (+++) or minus CD41 (++-) demonstrated
minimal but detectable repopulating ability in the competitive repopulation
assay. Marrow cells with the phenotype
Kit+CD34-CD41+ (+-+) demonstrated slightly
greater repopulating ability than the +++, or ++- cells (P>0.05). Marrow
cells with the phenotype Kit+CD34-CD41- (+-)
demonstrated significantly greater (P<0.05) repopulating ability than all
other sorted donor cell populations.