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Fig. 2. Kek1 antagonizes DER activity in the eye and wing. (A-H) Eye phenotypes. (A) A wild-type adult eye posses around 750 ommatidia arranged in a highly ordered pattern. (B) Eyes from kek1 mutants look wild type. (C) Elp/+ eyes are rough and this phenotype is strongly enhanced when homozygous for kek1 (D). Elp/Elp eye (E). UAS-kek1/GMR-Gal4 (F) and UAS-(kek1)2/GMR-Gal4 (G) are rough and reduced in size, similar to UAS-DERDN/GMR-Gal4 eyes (H). (I-N) Wing phenotypes. (I) A wild-type adult wing with its five longitudinal veins and two crossveins. (J) Wings from kek1 mutants look wild type. (K) Elp/+ wings have a weak extra wing vein phenotype (arrows), and this phenotype is enhanced when homozygous for kek1 (L). Overexpression of UAS-kek1 using MS1096-Gal4 results in severe reduction in the vein material (M), similar to UAS-DERDN overexpression (N).