Fig. 1. Hydrocephalus in adult transgenic mice. (A) Two mice in lateral (top) and frontal (bottom) view at about 2 months of age, showing the characteristic domed head and lateral displacement of the ears in the transgenic mouse compared with its wild-type littermate. (B) Parasagittal sections, stained with Hematoxylin and Eosin, of brains from four littermate mice, three transgenic and one wild type, at about seven weeks of age. The marked dilatation of the lateral ventricles (LV) is obvious in the transgenic mice; however, there is no evidence for dilatation of the fourth ventricles (arrows). Scale bar: 1 mm.