Fig. 2. Hydrocephalus in newborn transgenic mice. Serial rostral (r) to caudal (c) coronal sections, stained with Hematoxylin and Eosin, from newborn (P0.5) transgenic and wild-type littermates are shown, with each pair of sections representing approximately the same coronal plane. Note the extreme hydrocephalus apparent in the olfactory ventricles (OV) and the lateral ventricles (LV) of the transgenic compared with the wild-type mouse. In the more posterior sections, note the similar appearance of the aqueduct of Sylvius (aq) and the fourth ventricle (fv) in the wild-type and transgenic mice.