Fig. 5. Alignment of mouse, human and zebrafish RFX4_v3. The predicted protein sequences from these three RFX4_v3 orthologs were aligned using ClustalW. The position of the characteristic RFX DNA binding domain (DBD) is indicated by the box; other boxes contain the B and C boxes, and the dimerization domain (DD). The shaded first 14 amino acids labeled exon 1 were unique to RFX4_v3 (human); the next unshaded sequences represent exons 2-5 and are identical to sequences from RFX4_v2; the next shaded sequences represent exons 6-15 and are identical to sequences from both RFX4_v1 and RFX4_v2; the next unshaded sequences represent exons 16-18 and are identical to sequences in RFX4_v1. Asterisks indicate amino acid identity; double dots indicate a high degree of amino acid similarity; single dots indicate less similarity.