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Fig. 3. ADAMTS20 protein structure and homologies. (A) The protein structure of the products of the short and long Adamts20 transcripts are shown. ADAMTS9 is the most closely related mammalian homolog of ADAMTS20, and GON-1 is the highly homologous C. elegans metalloprotease. (B) ClustalW analysis of the ADAMTS family. The human (h) family members are shown because these are the most well characterized. The closely related ADAMTS20 orthologs, ADAMTS9, GON-1 and the Drosophila gene GH1639p are shown in bold.