Fig. 1. Localisation of DNA label-retaining cells in three whole-mount preparations of a mouse tail epidermis. In this procedure, 10-day old mice receive four injections of BrdU over 48 hours to label mitotic cells. After a 70-day chase period, a whole-mount preparation of tail epidermis is immunolabelled for keratin 14 (red) and BrdU (green; to detect label-retaining cells, LRCs). HF, hair follicle; IFE, interfollicular epidermis; SG, sebaceous gland.