Fig. 2. Positions of palmitoylated cysteines in Hh and Wnt. Palmitoylated cysteines (C) are shown in bold. In Hh, this cysteine is at the N terminus after the signal sequence (underlined) has been removed (Pepinsky et al., 1998). The cysteine in the Wnt protein Wnt3A and, by homology, in Wingless (Wg; shown here), is internal. However, this does not exclude the possibility that Wnt carries additional modifications at other sites. In both Hh and Wnt, there are basic residues downstream of the modified cysteine (shown in red).