Fig. 6. K252a reduces oocyte survival in newborn mouse ovaries in culture, but does not affect the distribution of oocyte diameters in surviving follicles. (A) The total number of follicles in uncultured day 0 ovaries and ovaries cultured in 0 nM, 50 nM and 100 nM K252a. Asterisks indicate significant difference compared with control culture (D7 0 nM), P<0.005. (B) The proportion of follicles containing oocytes of various diameters in uncultured day 0 ovaries. (C) The proportion of follicles containing oocytes of various diameters in ovaries cultured in 0 nM, 50 nM and 100 nM K252a. Line between B and C shows the follicle stage that corresponds to different diameters of oocytes.