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Fig. 4. Inhibition of PND migration following injection of function-blocking antibodies. Stage 21 embryos were injected with Fabs either against BSA or that specifically block integrin subunit function. (A) A BSA-injected control embryo in which the PND was found to have migrated normally. The PND tip (arrow) is at LS MINUS 1 in this embryo. (B) Following exposure to {alpha}6-integrin-function-blocking Fabs, PND migration has been inhibited, such that the PND tip (arrow) is at LS MINUS 3.5. (C) An embryo that has been coinjected with {alpha}6- and ß1-integrin-function-blocking Fab fragments. These antibodies caused a significant inhibition of PND migration, such that the tip is located at LS MINUS 7 rather than its normal position of about LS MINUS 1 to LS MINUS 2.