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Fig. 8. NT4/5 but not BDNF is essential for dendritogenesis. Apical and basal dendritic length and number of segments were quantified for pyramidal neurons in layer VI in the following conditions (indicated on the abscissa): SBA+, EGFP transfectants in active OTC; SBA–, EGFP transfectants in deprived OTC; BDNF SBA–, BDNF transfectants in deprived OTC; NT4 SBA–, NT4/5 transfectants in deprived OTC; anti-BDNF SBA+, EGFP transfectants in active OTC treated with neutralizing antibodies against BDNF from 5-10 DIV; antiNT4 SBA+, EGFP transfectants in active OTC treated with neutralizing antibodies against NT4/5 from 5-10 DIV; K252a, EGFP transfectants in active OTC treated with K252a from 5-10 DIV; BDNF K252a, BDNF transfectants in active OTC treated with K252a from 5-10 DIV; NT4 K252a, NT4/5 transfectants in active OTC treated with K252a from 5-10 DIV. The numbers in the bars represent the number of dendrites analyzed. For apical dendrites they equal the number of neurons analyzed. *=P<0.05; **=P<0.01, Mann-Whitney-U-tests versus SBA+ condition.