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Fig. 1. Germ cell specification in model systems. (A) A cellular blastoderm stage D. melanogaster embryo stained with anti-Vasa antibody. The pole cells (arrowhead), located at the posterior pole of the embryo, are the primordial germ cells (PGCs), and express vasa protein. (B) Mouse embryo at 7 dpc stained with alkaline phosphatase. Enzymatic activity is high in the PGCs (arrowhead), which are located in the proximal epiblast at the base of the allantois [Reproduced with permission from McLaren (McLaren, 2003)]. Anterior is to the left in both panels.