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Fig. 1. Map of Cct1 mutations and alignment of predicted CCT protein sequences. (A) Deletions were generated in Cct1 and Cct2 by mobilization of the P-element BN81 (indicated by green arrowhead), which is inserted at nucleotide 57 in the 5'UTR of Cct1 (AY051993). Excisions are shown as green bars. The genomic rescue construct is shown as a blue bar. (B) Predicted protein sequences of Drosophila melanogaster Cct1 (NP_728628), Drosophila melanogaster Cct2 (NP_647622), Saccharomyces cerevisiae CCT (NP_011718) and Rattus norvegicus CCT{alpha} (NP_511177) were aligned using ClustalW. Identical residues are indicated in bold and dark gray; similar residues are indicated in light gray.