Fig. 3. Comparison of gene expression profiles of ß-catenin and Cripto or Wnt3 mutant embryos. Fold changes of expression of selected genes in mutants compared with wild-type embryos, and the tissue specific expression of these genes in wild-type embryos are shown. Genes were selected from all genes that are deregulated in the respective mutants (see http://www.mdcberlin.de/~zelldiff). (A) Genes commonly deregulated in both ß-catenin and Cripto mutants at E6.0. Upper panel, commonly downregulated genes with putative signalling or developmental functions; lower panel, commonly upregulated genes of which ESTs have been preferentially isolated from neural tissues. (B) Genes commonly downregulated in both ß-catenin and Wnt3 mutants at E6.5. Upper panel, genes downregulated specifically at E6.5 (late genes); lower panel, genes deregulated at both E6.5 and E6.0 (early genes); in brackets, fold change at E6.0. nd, not determined. Red, high relative expression; blue, low relative expression; bright area, genes with consistent measurements; dark area, genes with variable or low measurements in certain tissues.