Fig. 6. ed produces a neurogenic phenotype in the Drosophila embryo. (A) Cuticle of a wild-type embryo showing the characteristic ventral denticle belts. (B) In ed germline clone embryos, lacking both maternal and zygotic ed expression, there is a ventral hole in the cuticle. (C) A wild-type embryo stained for the neuronal marker ELAV exhibits the condensed central nervous system. (D) An ed germline clone embryo displays a disorganized central nervous system with increased number of ELAV-positive cells, a phenotype typical of reduced N signaling.