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Fig. 10. Possible mechanism of PGC determination by E-cadherin-mediated cell interaction. PGC/allantois common precursors locate within the proximal region of extra-embryonic mesoderm. Cells losing E-cadherin expression move to the distal region of the extra-embryonic mesoderm and differentiate into allantois. In contrast, some cells continuously expressing E-cadherin form clusters and E-cadherin-mediated cell signaling directs them to germ cell fate. exee, extra-embryonic ectoderm.