Fig. 2. The C-terminal domain of DPY-21 is conserved between species. In the alignment of the C terminus (amino acids 1224-1641), black indicates sequence identity, and gray represents sequence similarity. DPY-21 contains no identifiable motifs. However, the C-terminal region of DPY-21 appears to be conserved throughout evolution. No other significant similarity was found between DPY-21 and the putative homologs, as they are rendered in current data bases. The function of these DPY-21 homologs has not been determined. Locations of dpy-21 mutations are indicated by the + symbol.