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Fig. 9. Hox paralog group four gene expression is altered in Cdx1-and RARE-null mutants. In situ hydridization analysis of (A,D,G) wild type, (B,E,H) Rare-/- and (C,F,I) Cdx1-/- specimens for Hoxa4 (A-C), Hoxb4 (D-F) or Hoxd4 (G-I). Somite number is indicated in each panel commencing with the anterior-most limit of detection of each Hox gene. Hoxb4 and Hoxd4 exhibited similar posteriorization by one somite in both RARE (E,H) and Cdx1 (F,I) mutants, while Hoxa4 expression was unaffected (B,C). Note the low residual expression of Hoxb4 and Hoxd4 in somite 6 in both classes of mutants (E,F and H,I).