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Fig. 4. Cranial and frontonasal defects in PDGFR{alpha}fl/fl;Wnt1Cre embryos. (A-D) Ventral views of skeletal preparations from E17.5 wild type and NCC conditional embryos. (C,D) The mandible was removed for visualization of the palate. as, alisphenoid bone; bo, basioccipital bone; bs, basisphenoid bone; h, hyoid bone; m, maxilla; ps, palatal shelf; th, thyroid cartilage. *Cartilage remnants potentially from the hyoid horns. Note blood vessels prominent in D because of filling with India ink. (E,F) Frontal view of E11.5 PDGFR{alpha}fl/fl and PDGFR{alpha}fl/fl; Wnt1Cre+ embryos, respectively. The frontonasal masses fail to meet at the midline.