Fig. 4. Cortical neurotrophins regulate soma size in the SC. White bars represent contralateral and black bars ipsilateral values. The small insets indicate the percentage of median shifts in the individual animals: diamonds represent the total SGS neuron population, and circles the CB immunoreactive neuron population. Size frequency histograms reveal that (A) cortical cytochrome C control was not effective (MWU-test ipsi versus contra P>>0.05 in all animals tested for both populations). (B) NT-4/5 however consistently induced shifts to larger the sizes in the total SGS neuron population (MWU-test P<0.0001 in all animals tested). (C) In contrast, BDNF infusions consistently induced shifts to smaller sizes in the total SGS neuron population. The median shifts for SGS neurons (diamonds in the insets) are significantly different from cytochrome C values (one way ANOVA P<<0.05, Tukey's post hoc test). The CB neurons (circles in the insets) did not undergo size shifts (one way ANOVA, Tukey's post hoc test).