Fig. 6. Size variation of cortical layer IV and LGN neurons in wild-type (WT) and synRAS-TG mice. White bars represent wild-type and black bars synRAS-TG values. (A) Layer IV neurons were consistently larger in the synRAS-TG mice (MWU-test, WT versus TG, P<0.0001). (B) However, there was no consistent trend to larger sizes in LGN neurons indicating that they do not adjust with larger sizes to the hypertrophic cortical neurons which develop postnatally in synRAS-TG mice. The small inset indicates the percentage of median shift observed in the five sibling pairs aged P40 and 3 months (diamonds) and in the three sibling pairs aged P13 and P30 (circles).