Fig. 7. Cluster analysis of expression profiles reveals the most predominant expression patterns as well as significant associations of gene annotations. (A) Means of the 20 largest of 106 total clusters are presented (including 79% of 3157 genes with P<0.001 in either within-series ANOVA). Clusters are numbered according to size (number of member genes in brackets) and arranged so that similar patterns are near each other. Axis labels are included for cluster 1 and are the same throughout. Line width reflects relative cluster size on a log scale. Bars reflect 1 s.d. among the members of the cluster. (B) Significant enrichments and depletions of gene annotations in expression clusters determined by a hypergeometric probability analysis (P<0.001). Coordinates for the clusters corresponding to A are given (row, column). Functional categories are from Worm Proteome Database (4 March 2002) (Costanzo, 2001). Abbreviations correspond to RNAi phenotypes from WormBase (Mei, defective meiosis; Led, late embryo defect; Bmd, body morphology defective).