Fig. 2. The hsy phenotype is caused by a disruption of foxi1. (A) Nucleotide sequence and predicted ORF of zebrafish foxi1 (GenBank Accession Number, AY204207). (B) Schematic of Foxi1 protein in wild type and hsy. A two-base deletion produces a frameshift in codon 41 and results in a truncated protein of 158 amino acids.