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Fig. 8. A model for the regulation of dHAND expression during craniofacial development. The expression domains of dHAND, eHAND and Dlx6 in the mandibular branchial arch of an E10.5 embryo are shown on the right side. Subdomains of dHAND expression are shown on the left side. ET-1 is secreted from the surface epithelium of the branchial arch (shown in brown) and acts on a 208 bp dHAND enhancer to induce a ventrolateral domain of dHAND (shown in red). The ventral domain of dHAND (shown purple) is regulated by unknown branchial arch enchancer(s) via a transcription factor (shown as a question mark) in response to ET-1. The most ventral tip of dHAND expression is regulated in an ET-1-independent manner (shown in dark blue).