Fig. 2. Growth of the colon in Igf2 knockout, wild-type and
K:Igf2 mice. (A) Lumenal area measured at 2-4 weeks of age. (B)
Semi-log plots of crypt numbers measured at 2-4 weeks of age. (C) Comparison
of crypt heights measured at 2 weeks and 12 weeks of age (K:Igf2
samples indicated by K2). Each animal was sampled in triplicate and results
averaged (medians indicated by horizontal bars, interquartile range by boxes
and full range by vertical capped bars); n
6 for each genotype
tested. Kruskal-Wallis test for significance: 2-week (columns 1-3)
P<0.0001; 12-week (columns 4-6) P=0.0284.