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Fig. 4. Rescue of Brachyury expression in A1-/-{gamma}-/- double mutant embryos. Brachyury expression patterns in the wild-type (A) and A1-/-{gamma}-/- (B) embryos are comparable, showing strong expression in the tail bud (tb) nascent mesoderm and neuroepithelium, as well as the notochord (nc). A1-/-{gamma}+/- (C) and A1-/- (D) mutants show eversion and twisting of tissues caudal to the posterior neuropore (PNP, arrowhead). Brachyury expression is severely downregulated in the A1-/- mutant tail bud (tb*), while notochord labeling stops abruptly at the level of the PNP (arrowhead).