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Fig. 2. Sequence alignment of C. elegans mat-1/cdc-27 and its homologs from humans, Drosophila, A. nidulans and S. cerevisae. Identical residues are highlighted in black, conservative changes in gray, and the mutant lesions are indicated in red. Tetratricopeptide repeat (TPR) domains are underlined and numbered. Hs, H. sapiens; Dm, Drosophila melanogaster; An, A. nidulans; Sc, S. cerevisiae and Ce, C. elegans. Numbers on left represent amino acid positions.