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Fig. 3. Characterization of amino acid sequences deduced from spider cDNA clones, At.dpp, At.fkh, At.otd and At.cad. Conserved amino acid residues in alignments are highlighted. Gaps introduced to optimize the alignments are indicated by dashes (A,D). (A) Amino acid sequence of the C-terminal domain of At.Dpp aligned with known Dpp/BMP2/4 family proteins and Drosophila 60A and Screw proteins. (Database Accession Numbers: Dm.Dpp, U63857; Tc.Dpp, U63132; Sg.Dpp, AF374725; Bf.BMP2/4, AF068750; Hr.BMPb, D85464; DrBMP-2, AF072456; DrBMP-4, D49972; Dm.60A, M84795; Dm.Screw, U17573.) (B) Amino acid sequence of the winged-helix (forkhead) domain of At.Fkh aligned with known Fkh/HNF-3 family proteins and Drosophila FD1 and FD3-FD5 proteins. (Database Accession Numbers: Dm.Fkh, J03177; Tc.Fkh, AF217810; Bf.HNF3-,1 X96519; Hr.HNF-3, AB007406; DrAxial, Z22762; Dm.FD1 and FD3-FD5, M96440 and M96442-M96444.) (C) Amino acid sequence of the homeodomain and C-terminal hexapeptide of At.Otd aligned with known Otd/Otx family proteins and Drosophila Otp, Prd and Gsb proteins. Dashes indicate the varied numbers of amino acid residues omitted. (Database Accession Numbers: Dm.Otd, X58983; Tc.Otd1 and 2, AJ223627 and AJ223614; Bf.Otx, AF043740; Ci.Otx, AF305499; DrOtx2, D26173; Dm.Otp, NM-079075; Dm.Prd, M14548; Dm.Gsb, NM-079139.) (D) Amino acid sequence of the homeodomain of At.Cad aligned with known Cad/Cdx family proteins and Drosophila Dfd, Scr and Antp proteins. (Database Accession Numbers: Dm.Cad, NM-134301; Bm.Cad, D16683; Tc.CadA and B AJ00542 and AJ005422; DrCad1, X66958, Dm.Dfd, X05136; Dm.Scr, X14475; Dm.Antp, M20704.) Abbreviated species are as follows: Dm, Drosophila melanogaster; Tc, Tribolium castaneum; Sg, Schistocerca gregaria; Bm, Bombyx mori; Bf, Branchiostoma floridae; Hr, Halocynthia roretzi; Ci, Ciona intestinalis; Dr, Danio rerio.