Fig. 1. Conserved Foxa2 consensus binding sites in the MAP1B promoter. Schematic representation of the MAP1B promoter highlighting potential Foxa2 binding sites (asterisks) on previously characterized A, B, C, D and E fragments (modified from Montesinos et al., 2001). Fragment C rat (top) and human (bottom) sequences have been aligned. Four ATTA (square boxes) and five Foxa2 consensus binding sites (oval boxes, core underlined) are conserved between rodent and human. Note that, in two regions, the putative homeoprotein and Foxa2 sites overlap (HF1 and HF2). Residues that differ between rat and human sequences are shaded in black.