Fig. 6. Three dimensional reconstruction of E16.5 inner ears using 6 µm tissue sections. Lateral and medial views are shown. am, ampulla; other abbreviations as in Figs 1,2,3,4. Sensory patches are marked in the cochlea (dark blue), saccule and utricle (light blue), and in the ampullae (purple). In spite of the enormous expansion in the Foxi1^-/- inner ear, the sensory patches can be identified at approximately the correct locations. In the tissue sections used in this experiment the sensory areas appear normal in all three genotypes (not shown). Scale bar: 100 µm.