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Fig. 8. Morphology of the otoconia, at E16.5, in Foxi1+/- (A) and Foxi1-/- (B) inner ears. The white utricular (uo) and saccular (so) otoconia are not formed properly (arrows) in Foxi1-/- mice (B). This finding suggests a defect in proper crystallization of calcium carbonate crystals normally found in the otoconia. In this mouse strain (CD-1), the perimeter of the oval window (ow) has a white color. Scale bar: 250 µm.