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Fig. 8. Gastrulation initiates in Lama1-/-; Mr5 embryos, as demonstrated by in situ hybridization of a digoxigenin-labeled brachyury (T) cRNA probe to frozen sections of E7.5 embryos. (AD) Two control/Lama1-/-; Mr5 embryo pairs from two different litters. Despite the aberrant shape of the Lama1-/-; Mr5 embryos, robust expression of brachyury is evident. (E,F) Brachyury expression in a Lama5-/- embryo is similar to the control.