Fig. 7. Ftz modulates Runt-dependent activation and repression of wg and en. Expression of wg (A-D) and en (E-H) in response to different perturbations in Runt and Ftz activity. (A,E) Response of these two genes to transient elimination of run in a temperature-shifted run[YP17] embryo. (B,F) Response to NGT-driven Ftz. These embryos are from a mating of homozygous NGT40 females to homozygous UAS-ftz[261] males. (C,G) NGT-driven co-expression of Runt and Ftz blocks wg expression, while producing a pair-rule pattern of en expression. (D) Response of wg to NGT-driven co-expression of Runt and Opa. This embryo is from a mating of females homozygous for both NGT40 and NGTA to males homozygous for the UAS-runt[13] and UAS-opa[14] transgenes. This combination results in a slp1 pattern similar to the embryos in Fig. 4F,H. (H) Response of en to NGT-driven Runt in embryos that are also homozygous for the ftz[11] mutation. This embryo is from the same cross used to generate the embryo in Fig. 5C.