Fig. 3. Oligodendroglial development in the embryonic spinal cord of mice carrying Sox8 and Sox10 null alleles. Immunohistochemistry with antibodies specific for the oligodendrocyte marker Olig2 (A-D), and in situ hybridization with probes specific for Mbp (E-H) and Plp (I-L) were performed on transverse sections from the forelimb region of embryos at 18.5 dpc. (A,E,I) Wild-type spinal cords; (B,F,J), Sox8^lacZ/lacZ spinal cords; (C,G,K), Sox10^+/lacZ spinal cords; (D,H,L), Sox8^lacZ/lacZ, Sox10^+/lacZ spinal cords.